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Presentation
The network and its partners
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Presentation of the CENTAURE research network
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The CENTAURE network
Today, the three core centers of the CENTAURE network are currently carrying out a major part of transplantations performed in France. They have played a key role in the development of the sciences of transplantation. The core centers of CENTAURE are designated by a*, the other centers being associated with the core centers:
- The Institute for Transplantation and Research in Transplantation (ITERT*), Nantes University Hospital , University of Nantes
- The Departments of Transplantation at the Hospices Civils de Lyon*, Claude Bernard University Lyon 1 and the department of Maxillo-Facial Surgery at the Amiens University Hospital, working in tight collaboration with Lyon for the transplantation of composite tissues;
- The Nephrology Department A1 Transplantation for adults*, Necker Hospital - Sick Children
- The Department of Clinical Immnunology*, Necker Hospital – Sick Children 4 The Department of Anatomopathology *, Necker Hospital – Sick Children 4 Eight INSERM / CNRS following units:
- Nantes: UMR 643*, UMR 649
- Lyon: UMR 103*, UMR 449, UMR 503*, one CNRS unit at the Institute of Cognitive Sciences in Lyon
- Paris : UMR S 775*, UMR 580*
The laboratories are part of 4 IFR (the IFR26 in Nantes, the IFR 19 in Lyon and the IFR 94 in Paris) and three doctoral schools;
Various recognized teams: the mixed HCL-Biomérieux unit in Lyon (Directed by P. Miossec), the Laboratory of Immune Monitoring, Hospital Louis Pradel in Lyon, the Histocompatibility Laboratory EFS / University of Nantes (Dr Bignon), the Laboratory of Immunology (Dr JY Muller), Hôtel Dieu –Nantes University Hospital.
The core centers’ contribution
for the development of the sciences of transplantation
France has played a founder role in organ transplantation, sharing the pioneering period for kidney transplantation with the United States (American professors JP Merrill and J. Murray trained at Pasteur and J. Hamburger in Paris) and for pancreas transplantation, for the technical adjustment which allowed its development. The three cores CENTAURE centers (Nantes, Lyon and Necker/Paris) currently carry out a major part of the transplantations performed in France. In various ways these centers have also played a key role in this development.
Here are examples of major innovations from core centers which are catering to the CENTAURE's teams:
- First xenograft in human in 1906 (M Jaboulay - Lyon), description of the vascular anastomosis and first transplants in animals (Lyon, A Carrel 1906)
- First living kidney transplant in man in 1952 and second world transplant between homozygotic twins. (J Hamburger-Paris)
- Xenograft chimpanzee to man in 1963 (J Traeger - Lyon),
- First cadaver graft with the longest survival in 1964 (Crosnier- Kreis)
- Introduction of Collins preservation solution in France in 1972 (Kreis-Paris)
- Research leading to of anti-lymphocyte serum development in 1967 – Lyon
- First European pancreas transplant in 1976 (JM Dubernard – Lyon)
- First fœtal tissue transplant in child in 1978 (JL Touraine, Lyon),
- First use of the monoclonal antibody OKT3 in 1982 in France (Kreis-Paris)
- First liver transplant in child from a living-related donor in1988 in France (O Boillot, Lyon)
- First hand transplant in 1998 (Lyon)
- First double hand transplant in 2000 (Lyon)
- Fifth renal transplant (Legendre-Paris)
- Face transplantation with the Amiens hospital (Lyon 2006)
- First use of anti IL2-R (1987) of anti-LFA1 and of anti-CD4 (Nantes)
- Introduction of the concept of transplantation without steroids (Nantes)
- Xenograft: first French research program with transgenic pigs and obtention of “academic pigs” for xenograft and neuronal tissue (CD55/56 and CTLA4-Ig) (Nantes)
- Creation of several biotechnology companies (Nantes)
Integration of CENTAURE to the major international research networks
The CENTAURE teams are part of large European transplantation-related networks (Demonstration, Integrated research program, Indices of tolerance, RISET, Xenome) in the field of transplantation. The CENTAURE teams take part in the following common or differential research networks:
- “Indices of Tolerance”, Demonstration, FP6 (JP Soulillou co PI)
- Reprogramming the Immune System for the Establishment of Tolerance (RISET), FP6 (Integrated Research program) (L. Chatenoud, Necker/Paris, Co-PI and leader of Clinical Research WP; C. Cuturi, ITERT, co PI leader of the animal experimentation WP)
- Immune Tolerance Network (ITN) L. Chatenoud/J.P. Soulillou
- « Xenome », FP6 (Integrated Research program) specializing in xenotransplantation (J.P. Soulillou, co-PI, G. Blancho and B. Charreau, WP leaders, ITERT)
- Clinigen, European Network of Excellence (NOE) (UMR 649, P. Moullier)
- The FOCIS network of centers of excellence (ITERT, correspondent : I. Anegon)
- « Cooperative Agreement » between the INSERM, U649 and the University of Florida
- The National Reference Centre AFLM (Universities of Nantes and Lyon)
- The Franco-Swiss network for pancreatic islets GRAGIL (co-founder: Lyon – collaboration with Geneva and Grenoble)
- Collaboration with Barcelona, Lyon, Brussels and Nantes for markers of tolerance following liver transplantation
- Collaboration with the University of Cambridge for the transplantation of embryonic neuronal tissue.
