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Presentation
The network and its partners
History of transplantation  |
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Supported projects of the 1st Joint Program of Activity : Nov 07 - Oct 08
The list of projects included in the Joint Program of Activities (PAC1) of the foundation is described below. Projects – from October 2007 to November 2008 – have been accepted and approved after the first call for tender.
Aim 1 – study of the mechanisms of allograft tolerance
- Determine the role of CLEC-1, a C-type lectin receptor, in immune tolerance. Elise Chiffoleau
- Study of the mechanisms of allograft tolerance in experimental models and in humans. Sophie Brouard
- Control of regulatory T cells by dendritic cells: molecular mechanisms and therapeuthic potential. Régis Josien
- Study of mechanisms in allograft tolerance induction by the administration of non-mature dendritic cells coming from autologous bone-marrow and setting up of a pre-clinical model. Cristina Cuturi
- Immunomodulation by mesenchymatous stem cells: Study of mechanisms which regulate in vivo allogenic anti-genic answer. Emmanuel Morelon
- Use of a humanized monoclonal antibody anti-CD3 in renal transplantation. Christophe Legendre
- Actions of mechanisms for non mitogenic anti-CD3 antibody in transplantation. Lucienne Chatenoud
- The Induction of graft tolerance by monoclonal anti-CD3 antibodies: setting and use of an experimental model allowing the evaluation of human anti-CD3 antibodies in clinical development. Lucienne Chatenoud
Aim 2 – Understanding and dissecting the causes of late graft loss
- To understand and to prevent endothelial dysfunctions linked to chronic rejection: the role of MHC molecules of class I, non classical expressed by the endothelium in graft rejection. Béatrice Charreau
- Understanding and dissecting the causes of late graft loss. Jean-Paul Soulillou
- Physiopathological mechanisms of the nephrotic idiopathic syndrome. Jacques Dantal
- Is lymphoid neogenesis a therapeutic target to prevent chronic rejection in humans? Olivier Thaunat
- Topology of alloimmune response: the role of macrophage cells in setting up intra-graft allo-immune response during experimental chronic rejection. Olivier Thaunat
- In vivo monitoring of specific beta cells and lymphocytes T cells during allografts or during autoimmune reactions. Charles Thivolet
- Clinical evaluation of immunological parameters for the individual adjustment of the immunosuppressive treatments for recipients of kidney allograft coming from living donors. Christophe Legendre
- The impact of the c-jun amino-terminal kinase mechanism in cyclosporine nephrotoxicity. Dany Anglicheau
- Automatic quantification of interstitial fibrosis on graft biopsies and long term consequences. Eric Thervet
Aim 3 – To establish a European center of reference in the field of transplantation in diabetic patients
- Prospective, open, randomized, including several centres and international study, comparing isolated pancreas graft impact and insulin intensive treatment, on patients survival and on the evolution of nephropathy, with diabetic patients which are insulin-dependent without terminal chronic renal failure. Diego Cantarovich
Aim 4 – New frontiers in transplantation: setting up innovative programs (xenotransplantation, composite tissue transplantation, personalized medicine: post-genomics)
- Study of hyperacute humoral rejection in baboons. Gilles Blancho
- Evaluation of costimumation blockage by CD40Ig and/or sc28AT in a renal transplant model in primates after gene transfer by AAV. Bernard Vanhove
- Characterization and control of neuroimmune interactions in intra-cerebral xenotransplantation. Hélène Boudin
- Analysis of the allo-immune response in composite transplantation. Assia Eljaarafi
- Feasibility of hand transplant for newborn infants with hand agenesis: immunological aspect of composite tissue transplantation for newborn pig. A Gazarian
Aim 5 – To develop the first European validated data bank for transplantation
- Project of a European Validated Data Bank in Transplantation: DIVAT. Magali Giral
- European Network of Validated data of the prancreas transplantation. Diego Cantarovich
- Setting up DIVAT in Lyon. Xavier Martin
- Setting up DIVAT in Paris. Christophe Legendre
Aim 6 – To foster relationships with biotechnology and pharmaceutical companies
- No current project.
Aim 7 - To develop the teaching of transplantation science from the bedside to the bench. To set up an organization to minimize the time necessary for the application of research discoveries to the clinic.
- Numeric campus: Transplantation from A to Z Xavier Martin